The Los Angeles Angels vs. Cubs (2-2) are set to face the Chicago Cubs (1-2) on Monday at Wrigley Field in Chicago, Illinois, with the first pitch scheduled for 7:40 p.m. ET. Let’s break down the MLB odds for this matchup and provide expert predictions and recommended bets.
2025 Season Series: Chicago leads 3-0
The Angels began their season with a 2-2 split in a four-game series against the Houston Astros. Los Angeles’ pitching staff allowed just two runs in their two wins but struggled on Saturday and Sunday, surrendering a combined 20 runs in high-scoring losses (11-9 and 9-7).
The Angels vs. Cubs, meanwhile, stay home after starting their 2026 campaign with a three-game series against the Washington Nationals at Wrigley Field. Chicago won on Saturday but lost both Thursday and Sunday, falling in the series 2-1.
Projected Starters:
- Angels: RHP Ryan Johnson
- Finished 2025 with a 1-1 record, 7.36 ERA, 1.98 WHIP, 3.1 BB/9, and 9.8 K/9 over 14 2/3 innings in 14 relief appearances.
- Began pro career in the Angels bullpen after being drafted in 2024, and ended 2025 at Single-A Tri-City with a 1.88 ERA in 12 starts.
- Posted a 3.05 ERA in 20 2/3 innings during spring training.
- Has never faced the Cubs.
- Cubs: RHP Edward Cabrera
- Making his Cubs debut; last year with the Miami Marlins, he went 8-7 with a 3.53 ERA, 1.23 WHIP, 3.1 BB/9, and 9.8 K/9 over 26 starts (137 2/3 innings).
- Had a rough spring, recording a 7.47 ERA in five games.
- Career vs. Angels: 1-0, 2.38 ERA in 11 1/3 innings (3 ER, 7 H, 6 BB, 15 K across two starts).
Angels at Cubs Odds (BetMGM Sportsbook, updated 1:48 p.m. ET):
- Moneyline: Angels +150 | Cubs -185
- Run Line / ATS: Angels +1.5 (-140) | Cubs -1.5 (+115)
- Over/Under: 9.5 (O +115 | U -105)
Game Analysis & Predictions:
Angels vs. Cubs Chicago has dominated recent matchups, winning the last four games against Los Angeles while outscoring them 24-6. The Cubs went 50-31 (.617) at home last season and, including playoffs, posted an 18-9 (.667) record after August 16.
Cabrera has shown improved velocity and a career-best walk rate recently. In his season-opening starts over the past three years with Miami, he allowed only five runs in 15 2/3 innings. He also has a strong Wrigley Field record, holding hitters to a .634 OPS over three career starts…Read more
Johnson remains less predictable. His solid Single-A ERA last year came in a pitcher-friendly league, making projections uncertain. Preseason forecasts see Chicago as NL Central contenders and Los Angeles as bottom-tier in the AL West.
Recommended Bets:
- Take Chicago -1.5 (+115) for the run line.
- The Over is favorable at Wrigley, where Chicago has gone 13-6-1 in its last 20 home games. Both bullpens currently show 3.00 ERAs, but early-season stats may be skewed by luck and availability issues. Combined with a forecast for an outward breeze, Over 9.5 (-115) is a strong option…Read more
For more betting advice and MLB picks, check SportsbookWire.com and BetFTW. All recommendations are independently chosen by our editors. Betting involves risk; never stake more than you can safely afford to lose.
